Epti Suspension 120ml Dosage Adults
100 mg two or four times before meals with max total of 600 mg daily. Titrate: Every 7-10 days. May give once daily if controlled on 300 mg/day. INJECTION: By slow IV injection or infusion (with blood pressure and ECG monitoring). Status epilepticus: 18 mg/kg at a rate not exceeding 50 mg per min, as a loading dose; maintenance doses of about 100 mg should be given thereafter at intervals of every 6-8 hr, monitored by measurement of plasma concentrations; rate and dose reduced according to weight. Children: Tonic-clonic seizures, focal seizures: IV INJECTION (over 20-30 minutes) or ORAL: Neonate, initial loading dose by slow IV injection (section 4.8.2) 18 mg/kg then by mouth 2.5-5 mg/kg twice daily adjusted according to response and plasma-phenytoin concentration (usual max 7.5 mg/kg twice daily). 1 mth-12 yr, Oral initially 1.5-2.5 mg/kg twice daily, then adjusted according to response and plasma-phenytoin concentration to 2.5-5 mg/kg twice daily (usual max 7.5 mg/ kg twice daily or 300 mg daily); 12-18 yr, Oral initially 75-150 mg twice daily then adjusted according to response and plasma phenytoin concentration to 150-200 mg twice daily (usual max 300 mg twice daily).seizures associated with head trauma or neurosurgery: Slow IV injection or infusion: Neonate, initially 20 mg/kg as a loading dose then 2.5-5 mg/kg twice daily; 1 mth-12 yr, initially 20 mg/kg as a loading dose then 2.5-5 mg/kg twice daily; 12-18 yr, initially 20 mg/kg as a loading dose then up to 100 mg 3-4 times daily.
Advice to Patient
Do not chew, crush or open capsules, swallow whole. Shake suspension well before use. Do not take antacids or calcium products within 2 hours of taking medication. Do not administer nasogastric or enteral feed to patients 2 hours before or after a dose. Do not change feed timings. Contact prescriber if there is change in mental status, unrelieved nausea, vomiting or constipation, speech impairment, chest pain, palpitations, irregular heartbeat, change in gait, swelling in glands, swollen/ sore/bleeding gums, skin rash, acute fatigue, change in vision, unusual bruising or bleeding. Avoid alcohol during therapy. Maintain good oral hygiene and dental care. If you have diabetes, check your blood