Eskem 20mg Capsules

Indications

Erosive reflux oesophagitis, prevention of relapse of oesophagitis, symptomatic treatment of GERD. Zollinger-Ellison syndrome, severe peptic ulcer bleeding (following endoscopic treatment). In combination with antibiotics for the eradication of H. pylori, healing of H. pylori-associated duodenal ulcer and prevention of relapse of H. pylori-associated peptic ulcers. Treatment and prevention of NSAID-associated peptic ulceration.

Dosage

ORAL: Adults: Erosive oesophagitis: 40 mg once daily for 4-8 wk. Prevention of relapse, 20 mg once daily. GERD without oesophagitis: 20 mg once daily for 4 wk. Maintenance, 20 mg once daily as required. Zollinger-Ellison syndrome: Initially 40 mg two times daily, can be altered according to response. Usual dose: 80-160 mg daily, doses over 80 mg must be given in two divided doses. Triple therapy vs H. pylori: 20 mg twice daily with amoxicillin 1 gm twice daily and clarithromycin 500 mg twice daily for 7 days. NSAID ulceration: 20 mg once daily for 4-8 wk, Prevention, 20 mg once daily. Children: Not recommended.

INJECTION:

Adults: Reflux oesophagitis: 40 mg once daily given as IV inj over a period of at least 3 min or as IV inf over a period of 10-30 min. Symptomatic treatment of reflux oesophagitis: 20 mg once daily, half of the reconstituted solution be given as IV inj over a period of at least 3 min or as IV inf over a period of 10-30 min. Healing of gastric ulcer associated with NSAID therapy & duodenal ulcers associated with NSAID therapy: 20 mg once daily to be given over atleast 3 min. Treatment duration is usually short and shift to oral dose as soon as possible. Severe peptic ulcer bleeding (following endoscopic treatment: Initial IV infusion of 80 mg over 30 min, then by continuous IV infusion 8 mg/hr for 72 hr, then by mouth 40 mg once daily for 4 wk. Children: By IV injection or by IV infusion. GERD in the presence of erosive reflux oesophagitis: 1-12 yr, body weight under 20 kg, 10 mg once daily; body weight over 20 kg, 10-20 mg once daily; 12-18 yr, 40 mg once daily. GERD in the absence of erosive reflux oesophagitis: 1-12 yr, 10 mg once daily; 12-18 yr, 20 mg once daily.