Doplet-3 Injection 1 Ampoules

Pregnancy

Doplet-3 Injection 1 Ampoules Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Hypercalcaemia, metastatic calcification, nephrolithiasis, hypercalciuria, nephrocalcinosis, hypervitaminosis De severe arteriosclerosis, pseudohypoparathyroidism, severe renal impairment. Precautions: Check plasma calcium and phosphate regularly. Long term treatment; monitor serum and urinary calcium and renal function. Cardiovascular disorders, Osteoporosis due to immobilisation.

Indications

ORAL: Simple vitamin deficiency. Vit D deficiency due to intestinal malabsorption or chronic liver disease. Hypocalcaemia due to hypoparathyroidism or in patients with renal osteodystrophy. INJECTION: Rickets, osteomalacia, Spasmophilia, paget’s disease, osteoporomalacia, fanconi syndrome.Doplet-3 Injection 1 Ampoules

Dosage

INJECTION; Orally or as IM Injection: Adults: 10 mg twice a yr (5 mg/dose). See literature. Children: Neonates, 10 mg twice a yr (5 mg/dose). See literature. ORAL: Simple vit D deficiency: Adults & Children: 10 mcg (400 units) daily. Secondary vit D deficiency: Adults & Children: Up to 1 mg (40,000 units) daily in divided doses. Hypoparathyroidism: Adults & Children: Up to 2.5 mg (100,000 units) daily Doplet-3 Injection 1 Ampoules.

 Advice to Patient

Take with or without meals. Preferably taken after meals. Chew the chewable tablets or wafers thoroughly before swallowing. Do not swallow whole wafers. Contact prescriber immediately if there is nausea, vomiting, constipation, loss of appetite, increased thirst, increased urination, mental or mood changes, unusual tiredness, rash, itching or swelling of face, tongue or throat; severe dizziness or difficulty in breathing. If you are also taking other medications, take cholecalciferol at bedtime. Give a gap of 2 hours or more between doses of bile acid sequestrants such as cholestyramine or colestipol, mineral oil, orlistat Doplet-3 Injection 1 Ampoules.

Pharmacokinetics

Absorption: Readily absorbed from the small intestine. Metabolism: Hepatic, renal. Half-life elimination: Approx. 50 days. Time to peak, plasma: 7 days. Excretion: Bile. Faeces.

Interactions

Doplet-3 Injection 1 Ampoules Barbiturates, anticonvulsants, danazol, digitalis, thiazides, antacids, mineral oils, cholestyramine, colestipol, Sucralfate, phenytoin, carbamazepine, glucocorticoids, digoxin, ion exchange resins, laxatives, orlistat, actinomycin, imidazole antifungals, rifampicin, isoniazid.

Adverse effects

Symptoms of overdose include anorexia, lassitude, nausea and vomiting, diarrhoea, constipation, weight loss, polyuria, sweating, headache, thirst, vertigo and raised concentration of calcium and phosphate in plasma and urine.