Indications

• Zepres 10mg is primarily indicated in conditions like Congestive heart failure, Diabetic retinopathy, Essential hypertension, Heart failure (adjunct), Hypertension, Left ventricular dysfunction, NSAID-associated gastric and duodenal ulcers, Renal hypertension, Severe or recurrent duodenal and gastric ulcertion, and can also be given in adjunctive therapy as an alternative drug of choice in Essential and renovascular hypertension.

Contraindication

• Zepres 10mg is contraindicated in conditions like Angioneurotic edema Aortic stenosis, Bilateral renal artey stenosis

Side Effects

• The severe or irreversible adverse effects of Zepres 10mg, which give rise to further complications include Hepatotoxicity, Anaphylactoid reactions, Vasculitis, Angioedema, Neutropenia, Acute renal failure, Hepatotoxicity, Angioedema. The signs and symptoms that are produced after the acute overdosage of Zepres 10mg include Hypotension. The symptomatic adverse reactions produced by Zepres 10mg are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Fatigue, Rashes, Dry cough, Taste disturbances, Azotemia, dizziness.

Warnings

• Enalapril should be used with caution in patients of renal insufficiency, severe liver dysfunction, hypervolemia, angioedema and in pre-existing bone marrow depression. Enalapril therapy can cause neutropenia or agranulocytosis. Patients with renal disease, patients with immunosuppression or receiving immunosuppressives, and patients with collagen vascular disease or autoimmune disease are at a greater risk for developing these complications. The dose should be adjusted in patients with renal impairment. It should be used cautiously in patients with congestive heart failure. Initial doses should be lower than in the treatment of hypertension becauseof a greater risk of developing hypotension. It should not be administered to patients with pre-existing renal artery stenosis. Renal function should be monitored closely during the first 2 weeks after initiating therapy. It should be discontinued if renal function worsens acutely. Other types of renal disease can actually improve during Enalapril therapy The dose should be adjusted in patients with renal impairment. It should be used with caution patients with hyperkalemia. It is classified as pregnancy category C and should be used with caution during pregnancy only if clearly needed.