Diu-Tansin is a prototype drug of thiazide diuretics Diu-Tansin is antihypertensive agent. It increases the urination and reduces the amount of water and sodium retained by the body. The drugs in this class are formally called benzothiadiazide, usually shortened to thiazides. The nature of the hetrocyclic rings and the substitution on these ring may vary among the congeners but all of them retain a unsubstituted sulfonamide group. Development of thiazides and other modern diuretics began when a perceptive physician noticed that patients receiving sulfanilamide, an early antimicrobial agent, developed metabolic acidosis and a very alkaline urine. Careful study revealed that the drug was causing sodium bicarbonate diuresis. The realization that it could be useful diuretic led first to the development of acetazolamide and then to the thiazides
Diu-Tansin is primarily indicated in conditions like Diabetes insipidus Edema, Hypercalciuria, Hypertension, Nephrolithiasis, Nephrotic syndrome, Oedema, Proximal renal tubular acidosis and can also be given in adjunctive therapy as an alternative drug of choice in Exercise induced hyperkalemia, Osteoporosis, Renal hypophosphatemicrickets
Diu-Tansin is contraindicated in conditions like Diabetes mellitus, Gout, Renal diseases. Anuria Hyperlipidemia Liver diseases, Ecg abnormalities
The severe or irreversible adverse effects of Diu-Tansin, which give rise to further complications include Pancreatitis, Stevens johnson syndrome, Stevens johnson syndrome, Systemic lupus erythematosus, Pneumonitis, Idiosyncratic hypersensitivly reactions. Diu-Tansin produces potentially life-threatening effects which include Hyponatremia, Metabolic disturbances, Hyponatremia, Idiosyncratic hypersensitivity reactions, which are responsible for the discontinuation of Diu-Tansin therapy. The signs and symptoms that are produced after the acute overdosage of Diu-Tansin include Coma, Volume depletion Hypokalemia, Hypochloremic alkalosis, Hypersensitivity reactions, Electrolyte disturbances, Lethargy, Hemolytic anemia, Hyponatremia. The symptomatic adverse reactions produced by Diu-Tansin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Thirst, Fatigue, Restlessness Dry mouth, Lethargy. Allergic reactions, Cardiac arrhythmias Hyperuricemia, Hypokalemia, Ectopic beats, Hypomagnesamia, Paralysis, UTI, Hyperlipidemia, Hyperglycemia, Dry mouth parasthesia.
Hydrochlorothiazide should be used with caution in patients with diabetes, kidney or liver disease or any drug allergy. Caution must be observed when eating large amounts of food high in potassium such as bananas, baked potatoes, raisins, cooked spinach and other foods. Alcoholic beverages may increase the effects of this drug. causing dizziness or lightheadedness, so limit alcohol intake. It should be used with caution while engaging in activities requiring alertness. This drug changes fluid balance, cause dizziness, if change from a lying to a standing position too rapidly avoid this by sitting up a few minutes before rising. It should be used with caution during pregnancy or lactation. Use with caution in certain pateints with 4% gout. Photosensensiation can occur exacerbation or actiration. Use with caution with moderate or high cholestraheacone
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies