Regulair Tablet 10mg is a nonsteroidal anti-inflammatory drugs (NSAIDs) possesses analgesic and antipyretic properties. Regulair Tablet 10mg is structurally unrelated to other NSAIDs. It has a long half-life and may be administered as a single daily dose, which can be an advantage over other NSAIDs. The anti-inflammatory potential of it has been equated with that of indomethacin, and its analgesic activity has been shown to be greater than that of aspirin. Regulair Tablet 10mg is indicated in the treatment of osteoarthritis and rheumatoid arthritis. It was approved by the FDA in 1982. The antiinflammatory effects of it may result from the peripheral inhibition of prostaglandin synthesis due to the inhibition of the enzyme cyclooxygenase. It also can inhibit the activation of neutrophils, which may contribute to antiinflammatory effects as well. Prostaglandins sensitize pain receptors, and their inhibition is believed to be responsible for the analgesic effects of it.
Indications Regulair Tablet 10mg is primarily indicated in conditions like Acute gout, Acute spasm and spasm in diagnostic procedures, Ankylosing spondylitis, Benign gastric and duodenal ulceration, Duodenal ulceration, Gout, Juvenile chronic arthritis, Musculoskeletal disorders, Nausea and vomiting (palliative care), Osteoarthritis, Pain, Resistant oedema, Rheumatoid arthritis.
Regulair Tablet 10mg is contraindicated in conditions like Peptic ulcer, Thrombosis, Impaired hepatic function.
The severe or irreversible adverse effects of Regulair Tablet 10mg, which give rise to further complications include Skin reactions, Erythema.Regulair Tablet 10mg produces potentially life threatening effects which include GI bleeding, Aplastic Anemia, Renal damage, Peptic ulceration, Purpura, Pemphigus vulagris, which are responsible for the discontinuation of Regulair Tablet 10mg therapy. The signs and symptoms that are produced after the acute overdosage of Regulair Tablet 10mg include Nausea, vomiting, Diarrhea, Hematuria, GI disturbances, Renal failure, Gl hemorrhage, Proteinuria, Hypoprothrombinemia. The symptomatic adverse reactions produced by Regulair Tablet 10mg are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Palpitation, Insomnia, Confusion, VertigoX, Hearing loss, Mood swings, Paresthesias, Hypoglycemia.
Regulair Tablet 10mg should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing controlled infection. Perform periodic auditory function test during chronic therapy. Discontinue drug if skin reaction occurs.