Ponstan is a NSAID (non steroidal antinflammatory drug). Ponstan is prepared by chemical synthesis and chemically Mefenamic Acid is N-2, 3-xyly anthranilic acid. Mefenamic Acid is used for its both antinflammatory and antipyretic properties. Mefenamic Acid is given by mouth to treat arthritis, headaches, menstrual cramps, muscle aches, dental pain
Mefenamic Acid is primarily indicated in conditions like Dysmenorrhoea, Fever, fever, Inflammation, Juvenile chronic arthritis, Menorrhagia, Migraine, Musculoskeletal disorders, Osteoarthritis Pain, Post-operative pain, Post-partum pain, Rheumatoid arthritis, Symptomatic relief of Gl-disorders, Toothache Traumatic pain.
The severe or irreversible adverse effects of Mefenamic Acid, which give rise to further complications include Diarrhoea, Peripheral edema, Urticaria, GI bleeding, Gl bleeding. Proteinuria, Aplastic anemia, Aplastic anemia, Epidermal necrolysis, Jaundice, Jaundice, Nephrotic syndrome, Interstitial nephritis, Papillary necrosis, Hemolysis, Proctocolitis, Enteritis, Large bowel perforation, Epidermal necrolysis, Platelet dysfunction, Aplastic anemia, Gl perforation, Proteinuria, proteinuria, Haemolytic anemia Mefenamic Acid produces potentially life-threatening effects which include Agranulocytosis. Thrombocytopenia, Pancytopenia, Leucopenia, Heart failure, Bone marrow hypoplasia, Reversible autoimmune hemolysis, which are responsible for the discontinuation of Mefenamic Acid therapy. The signs and symptoms that are produced after the acute overdosage of Mefenamic Acid include Grand Mal Seizures (epilepsy). Excitation, Depression, Incoordination. The symptomatic adverse reactions produced by Mefenamic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Skin rashes, Maculopapular rash, Hematuria, Elevation of liver enzymes, Anemia, Azotemia, Bullous rash, Skin rashes, dizziness.
Mefenamic acid should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension and other conditions predisposing to fluid retention. It should be used with extra care in the presence of existing uncontrolled infection Perform periodic auditory function test during chronic therapy Discontinue drug if skin reaction occurs
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies