Penorit Tablets is primarily indicated in conditions like Breast cancer, Breast cancer (unlicensed indication), Dysfunctional uterine bleeding, Gonadal dysgenesis, Heriditary haemorrhagic telangiectasia, Hormone replacement for menopausal symptoms, Hormone replacement therapy, Menopausal symptoms, Oestrogen deficiency, Osteoporosis prophylaxis, Pre-ovulatory mucus, Prostatic cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Acne, Contraception, Endometriosis, Hirsutism, Menstruation disorders.
Penorit Tablets is contraindicated in conditions like Thromboembolism, Genital bleed ing, Jaundice, Thrombophlebitis,Cerebrovascular disease, Hepatic carcinoma,Coronary artery disease,Estrogen-dependent cancer,Untreated endometriosis.
The severe or irreversible adverse effects of Penorit Tablets, which give rise to further complications include Impotence, Loss of libido, Gynacomastia, Chloasma, MI.Penorit Tablets produces potentially life-threatening effects which include Pulmonary embolism, Hypertension, Venous thromboembolism, Endometrial carcinoma, Endometrial hyperplasia, Cerebral thrombosis, Gall bladder disease, Liver tumors, Breast carcinoma, Venous thromboembolism, Coronary thrombosis. which are responsible for the discontinuation of Penorit Tablets therapy.The signs and symptoms that are produced after the acute overdosage of Penorit Tablets include Nausea, Vomiting, Coronary thrombosis, Uterine withdrawal bleeding. The symptomatic adverse reactions produced by Penorit Tablets are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Vomiting, Weight gain, Fluid retention, Intermenstrual bleeding or spotting, Chloasma, Cholestatic Jaundice, Vaginal candidiasis, dizziness.
High doses of Penorit Tablets used in treatment of malignant disease should be used with caution in patients with cerebrovascular disorder, coronary artery disease or venous thromboembolism. It should be used with caution in children, because premature closure of epiphysis may occur resulting in inhibited linear growth and small stature.