Risk Factor Pregnancy: Contraindicated in pregnancy.
recommended. Contraindications: Contains phenothiazine, avoid regular use as analgesic.
Indications As analgesic. Dosage Adults: 1 to 2 tab which may be repeated every 6 hr. Children: Not recommended.
Pharmacokinetics PARACETAMOL: Onset of action: Oral: <1 hr. IV: Analgesia: 5-10 min. Antipyretic: Within 30 min. Peak effect: IV: Analgesic: 1 hr. Antipyretic: =6 hrs. Absorption: Primarily absorbed in small intestine, minimal absorption from stomach (varies by dosage form). Metabolism: Hepatic. Half-life elimination: Neonates: 7 hrs. Infants: Approx. 4 hrs. Children: 3 hrs. Adolescents: Approx. 3 hrs. Adults: Approx. 2 hrs. CrCl<30 mL/min: 2-5.3 hrs. Time to peak, serum: Immediate release: 10.60 min IV: 15 min