Aerokast Tablets 5mg Interactions

Aerokast 5mg Phenobarbital, phenytoin, rifampicin, other enzyme inducers, gemfibrozil.Adverse effects Abdominal pain, headache, thirst, rarely anaphylaxis, angioedema, seizure, elevated ALT/AST, cholestatic hepatitis, Churg-Strauss syndrome (discontinue), GI upset, hyperkinesia.

Pharmacokinetics Duration

>24 hrs. Absorption: Rapid. Metabolism: Extensively hepatic. Bioavailability: Tab: 10 mg, Mean: 64%; Chewable tab: 5 mg: 73% (63% when administered with a standard meal). Half-life elimination: 2.7-5.5 hrs; Mild-to-moderate hepatic impairment: 7.4 hrs. Time to peak: Tab: 10 mg: 3-4 hrs (fasting); Chewable tab: 4 mg (children 2-5 yrs): 2 hrs (fasting); Chewable tab 5 mg: 2-2.5 hrs (fasting); Granules: 2.3 1 hrs (fasting) and 6.4 2.9 hrs (with high-fat meal). Excretion: Faeces (86%). Urine (<0.2%).

Dosage Adults

10 mg daily at bedtime with or without food. Children: Prophylaxis of asthma: 6 mth-6 yr, 4 mg once daily in the evening; 6-15 yr, Aerokast 10mg once daily in the evening; 15-18 yr, 10 mg once daily in the evening. Symptomatic relief of seasonal allergic rhinitis in children with asthma: 15-18 yr, 10 mg once daily in the evening.

Advice to Patient

Aerokast 5mg Take with or without meals. Take granules directly or mix with applesauce, carrots, sauce or icecream. Do not mix in liquids. Take within 15 minutes after opening packet. Contact prescriber if there is constant abdominal upset, abdominal pain, skin rash, skin itching, unusual cough or congestion, worsening of asthmatic condition. To relieve headache, mild pain-killer may be taken. If you have aspirin sensitivity, avoid aspirin and NSAIDs during therapy. On start of therapy or change of dosage, patient should be watched carefully for suicidal tendency by caregiver or family.